Regular Article IMMUNOBIOLOGY CD169 mediates the capture of exosomes in spleen and lymph node
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چکیده
solely due to preferential fluid flow to these areas. Although the circulation half-life of exosomes in blood of wild-type and CD169 mice was similar, exosomes displayed altered distribution in CD169 mice, with exosomes freely accessing the outer marginal zone rim of SIGN-R1 macrophages and F4/80 red pulp macrophages. In the lymph node, exosomes were not retained in the subcapsular sinus of CD169 mice but penetrated deeper into the paracortex. Interestingly, CD169 mice demonstrated an
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CD169 mediates the capture of exosomes in spleen and lymph node.
Exosomes are lipid nanovesicles released following fusion of the endosoma limiting membrane with the plasma membrane; however, their fate in lymphoid organs after their release remains controversial. We determined that sialoadhesin (CD169; Siglec-1) is required for the capture of B cell-derived exosomes via their surface-expressed α2,3-linked sialic acids. Exosome-capturing macrophages were pre...
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